![]() Wanders et al (1989) published the first case of biochemically proven LCHAD deficiency in a child, and the clinical profile of this metabolic disorder continues to evolve as more cases come to light. Since then, more evidence has accumulated to suggest that defects in fatty acid oxidation, especially deficiency of LCHAD, may be etiologically related to pregnancy-specific diseases, including preeclampsia, HELLP syndrome (hemolysis, elevated liver enzymes, low platelets), hyperemesis gravidarum, maternal floor infarct of the placenta, and AFLP. Schoeman et al (1991) first suggested a link between recurrent acute fatty liver of pregnancy (AFLP) and a defect in fatty acid oxidation. Long-chain L-3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) is an enzyme involved in the β-oxidation of long-chain fatty acids and has been under scientific scrutiny recently because of its reported association with certain pregnancy-specific disorders.
0 Comments
Leave a Reply. |